Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide

被引：72

作者：

Russ, MJ

Lachman, HM

Kashdan, T

Saito, T

Bajmakovic-Kacila, S

机构：

[1] Hillside Hosp, N Shore Long Isl Jewish Hlth Syst, Glen Oaks, NY 11004 USA

[2] Yeshiva Univ Albert Einstein Coll Med, Dept Psychiat, Bronx, NY 10461 USA

来源：

PSYCHIATRY RESEARCH | 2000年 / 93卷 / 01期

关键词：

hopelessness; serotonin; major depression;

D O I：

10.1016/S0165-1781(00)00128-1

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：73 / 78

页数：6

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