Pruritus in Cholestasis: Facts and Fiction

被引：176

作者：

Beuers, Ulrich ^{[1
]}

Kremer, Andreas E. ^{[1
,2
]}

Bolier, Ruth ^{[1
]}

Elferink, Ronald P. J. Oude ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, Tytgat Inst Liver & Intestinal Res, NL-1100 DD Amsterdam, Netherlands

[2] Univ Erlangen Nurnberg, Dept Med 1, Nurnberg, Germany

来源：

HEPATOLOGY | 2014年 / 60卷 / 01期

关键词：

LYSOPHOSPHATIDIC ACID PRODUCTION; PRIMARY BILIARY-CIRRHOSIS; INTRACTABLE PRURITUS; URSODEOXYCHOLIC ACID; LYSOPHOSPHOLIPASE-D; ITCH SENSATION; LIVER-DISEASE; SPINAL-CORD; BILE-ACIDS; AUTOTAXIN;

D O I：

10.1002/hep.26909

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Pruritus is a common symptom in patients with cholestatic liver diseases such as primary biliary cirrhosis, primary sclerosing cholangitis, intrahepatic cholestasis of pregnancy, or hereditary pediatric cholestatic disorders and may accompany, although less frequently, many other liver diseases. Recent findings indicate that lysophosphatidic acid (LPA), a potent neuronal activator, and autotaxin (ATX; ectonucleotide pyrophosphatase/phosphodiesterase 2), the enzyme which forms LPA, may form a key element of the long-sought pruritogenic signaling cascade in cholestatic patients suffering from itch. Serum ATX, but no other pruritogen candidate studied so far, correlates with pruritus intensity and responds to therapeutic interventions. In this comprehensive review, we provide a short update on actual insights in signal transmission related to pruritus and discuss pruritogen candidates in cholestasis. We also summarize evidence-based and guideline-approved as well as experimental therapeutic approaches for patients suffering from pruritus in cholestasis.

引用

页码：399 / 407

页数：9

共 36 条

[1]

The TGR5 receptor mediates bile acid-induced itch and analgesia [J].