Mechanisms by which exercise training benefits patients with heart failure

被引：103

作者：

Crimi, Ettore ^{[1
]}

Ignarro, Louis J. ^{[2
]}

Cacciatore, Francesco ^{[3
]}

Napoli, Claudio ^{[4
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Boston, MA 02114 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[3] Cardiovasc Rehabil Fdn Salvatore Mauge, IRCCS, Ist Sci Telese Terme & Campoli BN, San Giovanni Rotondo, Italy

[4] Univ Naples 2, Sch Med 1, Dept Gen Pathol, Clin Pathol & Excellence Res Ctr Cardiovasc Dis, Naples, Italy

来源：

NATURE REVIEWS CARDIOLOGY | 2009年 / 6卷 / 04期

关键词：

NITRIC-OXIDE SYNTHASE; LEFT-VENTRICULAR FUNCTION; QUALITY-OF-LIFE; SKELETAL-MUSCLE METABOLISM; SYMPATHETIC-NERVE ACTIVITY; BRAIN NATRIURETIC PEPTIDE; CORONARY-ARTERY-DISEASE; FAILING HUMAN HEART; FACTOR-I EXPRESSION; PHYSICAL-ACTIVITY;

D O I：

10.1038/nrcardio.2009.8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Clinical consequences of heart failure are fatigue, dyspnea, and progressive impairment of exercise tolerance. regular exercise training is associated with health-improving effects. in patients with stable heart failure, exercise training can relieve symptoms, improve exercise capacity and quality of life, as well as reduce hospitalization and, to some extent, risk of mortality. Progressive exercise training is associated with pulmonary, cardiovascular, and skeletal muscle metabolic adaptations that increase oxygen delivery and energy production. This review focuses on current knowledge of mechanisms by which progressive and moderate exercise training can have sustained beneficial effects on patients with heart failure.

引用

页码：292 / 300

页数：9

共 147 条

[1] Angina-induced protection against myocardial infarction in adult and elderly patients: A loss of preconditioning mechanism in the aging heart? [J].

Abete, P ;

Ferrara, N ;

Cacciatore, F ;

Madrid, A ;

Bianco, S ;

Calabrese, C ;

Napoli, C ;

Scognamiglio, P ;

Bollella, O ;

Cioppa, A ;

Longobardi, G ;

Rengo, F .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1997, 30 (04) :947-954

[2] High level of physical activity preserves the cardioprotective effect of preinfarction angina in elderly patients [J].

Abete, P ;

Ferrara, N ;

Cacciatore, F ;

Sagnelli, E ;

Manzi, M ;

Carnovale, V ;

Calabrese, C ;

de Santis, D ;

Testa, G ;

Longobardi, G ;

Napoli, C ;

Rengo, F .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 38 (05) :1357-1365

[3] Exercise training restores ischemic preconditioning in the aging heart [J].

Abete, P ;

Calabrese, C ;

Ferrara, N ;

Cioppa, A ;

Pisanelli, P ;

Cacciatore, F ;

Longobardi, G ;

Napoli, C ;

Rengo, F .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (02) :643-+

[4] Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fas ligand system in patients with chronic heart failure [J].

Adamopoulos, S ;

Parissis, J ;

Karatzas, D ;

Kroupis, C ;

Georgiadis, M ;

Karavolias, G ;

Paraskevaidis, J ;

Koniavitou, K ;

Coats, AJS ;

Kremastinos, DT .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (04) :653-663

[5] Physical training reduces peripheral markers of inflammation in patients with chronic heart failure [J].

Adamopoulos, S ;

Parissis, J ;

Kroupis, C ;

Georgiadis, M ;

Karatzas, D ;

Karavolias, G ;

Koniavitou, K ;

Coats, AJS ;

Kremastinos, DT .

EUROPEAN HEART JOURNAL, 2001, 22 (09) :791-797

[6] A glossary of circulating cytokines in chronic heart failure [J].

Adamopoulos, S ;

Parissis, JT ;

Kremastinos, DT .

EUROPEAN JOURNAL OF HEART FAILURE, 2001, 3 (05) :517-526

[7] CIRCADIAN PATTERN OF HEART-RATE-VARIABILITY IN CHRONIC HEART-FAILURE PATIENTS - EFFECTS OF PHYSICAL-TRAINING [J].

ADAMOPOULOS, S ;

PONIKOWSKI, P ;

CERQUETANI, E ;

PIEPOLI, M ;

ROSANO, G ;

SLEIGHT, P ;

COATS, AJS .

EUROPEAN HEART JOURNAL, 1995, 16 (10) :1380-1386

[8] Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease [J].

Adams, V ;

Linke, A ;

Kränkel, N ;

Erbs, S ;

Gielen, S ;

Möbius-Winkler, S ;

Gummert, JF ;

Mohr, FW ;

Schuler, G ;

Hambrecht, R .

CIRCULATION, 2005, 111 (05) :555-562

[9] Induction of iNOS expression in skeletal muscle by IL-1β and NFκB activation:: an in vitro and in vivo study [J].

Adams, V ;

Nehrhoff, B ;

Späte, U ;

Linke, A ;

Schulze, PC ;

Baur, A ;

Gielen, S ;

Hambrecht, R ;

Schuler, G .

CARDIOVASCULAR RESEARCH, 2002, 54 (01) :95-104

[10] Changes in brain natriuretic peptide and norepinephrine over time and mortality and morbidity in the Valsartan Heart Failure Trial (Val-HeFT) [J].

Anand, IS ;

Fisher, LD ;

Chiang, YT ;

Latini, R ;

Masson, S ;

Maggioni, AP ;

Glazer, RD ;

Tognoni, G ;

Cohn, JN .

CIRCULATION, 2003, 107 (09) :1278-1283

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