Novel synthetic oleanane triterpenoids: A series of highly active inhibitors of nitric oxide production in mouse macrophages

被引：72

作者：

Honda, T

Rounds, BV

Bore, L

Favaloro, FG

Gribble, GW

Suh, N

Wang, YP

Sporn, MB ^{[1
]}

机构：

[1] Dartmouth Coll, Dept Chem, Hanover, NH 03755 USA

[2] Dartmouth Med Sch, Dept Pharmacol & Toxicol, Hanover, NH 03755 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(99)00623-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel oleanane triterpenoids with modified rings A and C were designed and synthesized. Among them, methyl 2-carboxy-3,12-dioxooleana-1,9-dien-28-oate showed similar high inhibitory activity (IC50 = 0.8 nM) to 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), which we have synthesized previously, against production of nitric oxide induced by interferon-gamma in mouse macrophages. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：3429 / 3434

页数：6

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