Postmortem unenhanced magnetic resonance imaging of myocardial infarction in correlation to histological infarction age characterization

被引:92
作者
Jackowski, Christian
Christe, Andreas
Sonnenschein, Martin
Aghayev, Emin
Thali, Michael J.
机构
[1] Univ Bern, Ctr Forens Imaging & virtopsy, Inst Forens Med, IRM, CH-3012 Bern, Switzerland
[2] Univ Bern, Inst Diagnost Radiol, Inselspital, CH-3010 Bern, Switzerland
[3] Sonnenhof Spital AG, Dept Diagnost Radiol, CH-3006 Bern, Switzerland
关键词
virtopsy; magnetic resonance imaging; postmortem cardiac imaging; myocardial infarction; virtual autopsy;
D O I
10.1093/eurheartj/ehl255
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims Postmortem magnetic resonance (MRI) imaging is currently evaluated as alternative to traditional autopsy and myocardial infarction plays a key role therein. The aim of this study is to determine the suitability of postmortem MRI in infarction age staging. Methods and results In eight human forensic corpses presenting with a total of 11 myocardial infarcted areas, short-axis, transversal, and longitudinal long-axis images (T1, T2, stir, flair) were acquired in situ on a 1.5 T system. During subsequent autopsy, the section technique was adapted to short-axis images. Histological investigations were performed along the entire circumference of the left ventricle to correlate the signal alteration in MR to the histological appearance. Two peracute infarctions were not detected in MRI and autopsy. Four acute infarcted areas presented with decreased signal in necrotic centres and increased signal in marginal myocardial regions (T2-weighted). T1-weighted images showed local hyperintensities when intramyocardial haemorrhage occurred. Four cases showed subacute infarctions with hyperintense regions in T2-weighted images and no signal alteration in T1-weighted images. Four chronic myocardial infarctions showed distinctively decreased signals in all applied sequences. Conclusion Postmortem MRI demonstrates myocardial infarction in situ and allows for an infarction age estimation based on the signal behaviour.
引用
收藏
页码:2459 / 2467
页数:9
相关论文
共 49 条
[1]   Virtopsy post-mortem multi-slice computed tomograhy (MSCT) and magnetic resonance imaging (MRI) demonstrating descending tonsillar herniation: comparison to clinical studies [J].
Aghayev, E ;
Yen, K ;
Sonnenschein, M ;
Ozdoba, C ;
Thali, M ;
Jackowski, C ;
Dirnhofer, R .
NEURORADIOLOGY, 2004, 46 (07) :559-564
[2]  
AGHAYEV E, 2006, IN PRESS FORENSIC SC
[3]   EFFICIENT METHOD FOR SELECTING CARDIAC MAGNETIC-RESONANCE IMAGE LOCATIONS [J].
AXEL, L .
INVESTIGATIVE RADIOLOGY, 1992, 27 (01) :91-93
[4]   Myocardial contraction bands - Definition, quantification and significance in forensic pathology [J].
Baroldi, G ;
Mittleman, RE ;
Parolini, M ;
Silver, MD ;
Fineschi, V .
INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 2001, 115 (03) :142-151
[5]  
BOUCHARDY B, 1974, AM J PATHOL, V74, P301
[6]   Remodeling of cardiac fiber structure after infarction in rats quantified with diffusion tensor MRI [J].
Chen, JJ ;
Song, SK ;
Liu, W ;
McLean, M ;
Allen, JS ;
Tan, J ;
Wickline, SA ;
Yu, X .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2003, 285 (03) :H946-H954
[7]   SUDDEN CORONARY DEATH - FREQUENCY OF ACTIVE CORONARY LESIONS, INACTIVE CORONARY LESIONS, AND MYOCARDIAL-INFARCTION [J].
FARB, A ;
TANG, AL ;
BURKE, AP ;
SESSUMS, L ;
LIANG, YH ;
VIRMANI, R .
CIRCULATION, 1995, 92 (07) :1701-1709
[8]   Contrast-enhanced magnetic resonance imaging of myocardium at risk - Distinction between reversible and irreversible injury throughout infarct healing [J].
Fieno, DS ;
Kim, RJ ;
Chen, EL ;
Lomasney, JW ;
Klocke, FJ ;
Judd, RM .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (06) :1985-1991
[9]   HISTOPATHOLOGIC EVOLUTION OF MYOCARDIAL-INFARCTION [J].
FISHBEIN, MC ;
MACLEAN, D ;
MAROKO, PR .
CHEST, 1978, 73 (06) :843-849
[10]  
FISHBEIN MC, 1978, AM J PATHOL, V90, P57