Palladium catalyzed amination of 2-chloro-1,3-azole derivatives: Mild entry to potent H-1-antihistaminic norastemizole

被引：66

作者：

Hong, YP ^{[1
]}

Tanoury, GJ ^{[1
]}

Wilkinson, HS ^{[1
]}

Bakale, RP ^{[1
]}

Wald, SA ^{[1
]}

Senanayake, CH ^{[1
]}

机构：

[1] SEPRACOR INC,DEPT PROC RES & DEV,MARLBOROUGH,MA 01752

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(97)01273-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium-catalyzed selective amination of 4-fluorobenzyl-2-chlorobenzimidazole with 4-aminopiperidine provided a simple solution for the norastemizole synthesis. Pd-catalyzed amination of other 2-chloro-1,S-Azole derivatives are exploited. (C) 1997 Elsevier Science Ltd.

引用

页码：5607 / 5610

页数：4

共 22 条

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