Target selection for structural genomics

被引：91

作者：

Brenner, SE ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2000年 / 7卷 / Suppl 11期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1038/80747

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural genomics aims to use high-throughput structure determination and computational analysis to provide three-dimensional models of every tractable protein. The process of choosing proteins for experimental structure characterization is known as target selection. In this nomenclature, the targets are regions of proteins to be studied by crystallography or NMR. Selection of the targets is principally a computational process of restricting candidate proteins to those that are tractable and of unknown structure, and prioritizing according to expected interest and accessibility.

引用

页码：967 / 969

页数：3

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