Genomic organization and sequence conservation in type I Trichomonas vaginalis viruses

被引：26

作者：

Su, HM ^{[1
]}

Tai, JH ^{[1
]}

机构：

[1] ACAD SINICA, INST BIOMED SCI, DIV INFECT DIS, TAIPEI, TAIWAN

来源：

VIROLOGY | 1996年 / 222卷 / 02期

关键词：

D O I：

10.1006/viro.1996.0446

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To reveal the genetic conservation of type I Trichomonas vaginalis viruses (TW) we cloned and sequenced the 4.6-kb ds RNA of a TW-T5 isolate for comparison with the cDNA sequence of a related TW-T1 ds RNA. Analogous to TW-T1, the TW-T5 ds RNA also contains an upstream capsid protein gene overlapped with a downstream RNA-dependent RNA polymerase (RDRP) gene by a +1 reading frame shift. A conserved ribosomal slippage heptamer (C CUU UUU) was found within the consensus 14-nt overlap, and the context of the sequence surrounding the heptamer suggests a potential ribosomal frameshifting in the biosynthesis of RDRP from the initiation of capsid protein either through two consecutive -1 shifts or a +1 shift. (C) 1996 Academic Press, Inc.

引用

页码：470 / 473

页数：4

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