Circulation of subtype A and gagA/envB recombinant HIV type 1 strains among injecting drug users in St. Petersburg, Russia, correlates with geographical origin of infections

被引：49

作者：

Lukashov, VV

Huismans, R

Rakhmanova, AG

Lisitsina, ZN

Akhtyrskaya, NA

Vlasov, NN

Melnick, OB

Goudsmit, J

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Human Retrovirol, NL-1105 AZ Amsterdam, Netherlands

[2] Med Acad Postgrad Studies, Dept Infect Dis AIDS Course, St Petersburg 193015, Russia

[3] Clin AIDS Ctr, St Petersburg 193015, Russia

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1999年 / 15卷 / 17期

关键词：

D O I：

10.1089/088922299309874

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Countries of the former Soviet Union are experiencing an emerging HIV-1 epidemic due to a rapid expansion of HIV-1 among injecting drug users (IDUs), To study the molecular epidemiology of HIV-1 among IDUs in St. Petersburg, Russia, virus sequences were obtained from 22 individuals, Phylogenetic analysis of the env and gag regions revealed circulation of two major HIV-1 populations, one belonging to HIV-1 subtype A, and another being a recombinant of subtype A and B viruses (gagA/envB), Both virus populations were highly homogeneous, with a mean pairwise genetic distance of <2%, and similar to viruses obtained earlier from IDUs in other regions of the former Soviet Union. Distribution of the two major HIV-1 genotypes in St, Petersburg correlated with geographical origin of infections. In one individual a virus type previously unseen among IDUs was found, which demonstrates the possibility that new viruses are entering this risk group.

引用

页码：1577 / 1583

页数：7

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