LEDGF, a survival factor, activates stress-related genes

被引：130

作者：

Shinohara, T ^{[1
]}

Singh, DP ^{[1
]}

Fatma, N ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Dept Ophthalmol, Ctr Ophthalm Res, Boston, MA 02115 USA

来源：

PROGRESS IN RETINAL AND EYE RESEARCH | 2002年 / 21卷 / 03期

关键词：

LEDGF; heat shock element; survival factor; stress tolerance; stress-related element; transcriptional activator;

D O I：

10.1016/S1350-9462(02)00007-1

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

LEDGF is a survival factor and it enhances survival of various cell types against stress. LEDGF is also a transcriptional activator and it binds to promoter elements of heat shock and stress-related genes to activate expression of these genes. The elevated levels of the stress-related family of proteins, such as heat shock proteins, antioxidant proteins, and detoxication enzymes might suppress apoptosis induced by stress. The protective mechanisms against stress in mammalian cells and in yeast are surprisingly similar. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：341 / 358

页数：18

相关论文

共 121 条

[1] Lens epithelium-derived growth factor (LEDGF) delays photoreceptor degeneration in explants of rd/rd mouse retina [J].

Ahuja, P ;

Caffé, AR ;

Holmqvist, I ;

Söderpalm, AK ;

Singh, DP ;

Shinohara, T ;

van Veen, T .

NEUROREPORT, 2001, 12 (13) :2951-2955

[2]

Akimoto M, 1999, INVEST OPHTH VIS SCI, V40, P273

[3] Physiological functions of thioredoxin and thioredoxin reductase [J].

Arnér, ESJ ;

Holmgren, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (20) :6102-6109

[4]

AYAKI M, 2002, IN PRESS AUTOIMMUNIT

[5] Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome [J].

Beere, HM ;

Wolf, BB ;

Cain, K ;

Mosser, DD ;

Mahboubi, A ;

Kuwana, T ;

Tailor, P ;

Morimoto, RI ;

Cohen, GM ;

Green, DR .

NATURE CELL BIOLOGY, 2000, 2 (08) :469-475

[6] Inactivation of multiple targets by nitric oxide in CD95-triggered apoptosis [J].

Bernassola, F ;

Catani, MV ;

Corazzari, M ;

Rossi, A ;

Melino, G .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2001, 82 (01) :123-133

[7] ROLES OF GLYCEROL AND GLYCEROL-3-PHOSPHATE DEHYDROGENASE (NAD+) IN ACQUIRED OSMOTOLERANCE OF SACCHAROMYCES-CEREVISIAE [J].

BLOMBERG, A ;

ADLER, L .

JOURNAL OF BACTERIOLOGY, 1989, 171 (02) :1087-1092

[8] Msn2p and Msn4p control a large number of genes induced at the diauxic transition which are repressed by cyclic AMP in Saccharomyces cerevisiae [J].

Boy-Marcotte, E ;

Perrot, M ;

Bussereau, F ;

Boucherie, H ;

Jacquet, M .

JOURNAL OF BACTERIOLOGY, 1998, 180 (05) :1044-1052

[9] Hsp27 negatively regulates cell death by interacting with cytochrome c [J].

Bruey, JM ;

Ducasse, C ;

Bonniaud, P ;

Ravagnan, L ;

Susin, SA ;

Diaz-Latoud, C ;

Gurbuxani, S ;

Arrigo, AP ;

Kroemer, G ;

Solary, E ;

Garrido, C .

NATURE CELL BIOLOGY, 2000, 2 (09) :645-652

[10]

Cao W, 1999, J NEUROSCI RES, V57, P789, DOI 10.1002/(SICI)1097-4547(19990915)57:6<789::AID-JNR4>3.3.CO

← 1 2 3 4 5 6 7 8 9 10 →