Mitochondria, calcium and cell death: A deadly triad in neurodegeneration

被引：287

作者：

Celsi, Fulvio ^{[2
]}

Pizzo, Paola ^{[1
]}

Brini, Marisa ^{[3
,4
]}

Leo, Sara ^{[2
]}

Fotino, Carmen ^{[2
]}

Pinton, Paolo ^{[2
]}

Rizzuto, Rosario ^{[1
]}

机构：

[1] Univ Padua, Dept Biomed Sci, I-35121 Padua, Italy

[2] Univ Ferrara, Emilia Romagna Lab BioPharmaNet, I-44100 Ferrara, Italy

[3] Univ Padua, Dept Biochem, I-35131 Padua, Italy

[4] Univ Padua, Dept Expt Vet Sci, I-35020 Legnaro, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2009年 / 1787卷 / 05期

关键词：

Mitochondria; Calcium; Neurodegenerative disease; Alzheimer's disease; Parkinson's disease; Huntington's disease; AMYLOID PRECURSOR PROTEIN; PERMEABILITY TRANSITION PORE; ENDOPLASMIC-RETICULUM CA2+; CYTOCHROME-C-OXIDASE; ALZHEIMERS-DISEASE; HUNTINGTONS-DISEASE; INTRACELLULAR CA2+; OXIDATIVE DAMAGE; ATP PRODUCTION; CYCLOPHILIN-D;

D O I：

10.1016/j.bbabio.2009.02.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Mitochondrial Ca2+ accumulation is a tightly controlled process, in turn regulating functions as diverse as aerobic metabolism and induction of cell death. The link between Ca2+ (dys) regulation, mitochondria and cellular derangement is particularly evident in neurodegenerative disorders, in which genetic models and environmental factors allowed to identify common traits in the pathogenic routes. We will here summarize: i) the current view of mechanisms and functions of mitochondrial Ca2+ homeostasis, ii) the basic principles of organelle Ca2+ transport, iii) the role of Ca2+ in neuronal cell death, and iv) the new information on the pathogenesis of Alzheimer's, Huntington's and Parkinson's diseases, highlighting the role of Ca2+ and mitochondria. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：335 / 344

页数：10

共 112 条

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