A Nonself RNA Pattern: Tri-p to Panhandle

被引：27

作者：

Fujita, Takashi ^{[1
]}

机构：

[1] Kyoto Univ, Inst Virus Res, Dept Mol Genet, Kyoto 6068507, Japan

来源：

IMMUNITY | 2009年 / 31卷 / 01期

关键词：

RIG-I; RECOGNITION; RESPONSES; DOMAIN;

D O I：

10.1016/j.immuni.2009.06.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this issue of Immunity, Schlee et al. (2009) defines key RNA structures recognized by a cellular viral sensor, RIG-I. This and another recent report by Schmidt et al. (2009) provide new insights into the mechanism of antiviral innate immunity.

引用

页码：4 / 5

页数：2

共 9 条

[1] The C-terminal regulatory domain is the RNA 5′-triphosphate sensor of RIG-I [J].

Cui, Sheng ;

Eisenaecher, Katharina ;

Kirchhofer, Axel ;

Brzozka, Krzysztof ;

Lammens, Alfred ;

Lammens, Katja ;

Fujita, Takashi ;

Conzelmann, Karl-Klaus ;

Krug, Anne ;

Hopfner, Karl-Peter .

MOLECULAR CELL, 2008, 29 (02) :169-179

[2] 5′-triphosphate RNA is the ligand for RIG-I [J].

Hornung, Veit ;

Ellegast, Jana ;

Kim, Sarah ;

Brzozka, Krzysztof ;

Jung, Andreas ;

Kato, Hiroki ;

Poeck, Hendrik ;

Akira, Shizuo ;

Conzelmann, Karl-Klaus ;

Schlee, Martin ;

Endres, Stefan ;

Hartmann, Gunther .

SCIENCE, 2006, 314 (5801) :994-997

[3] Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 [J].

Kato, Hiroki ;

Takeuchi, Osamu ;

Mikamo-Satoh, Eriko ;

Hirai, Reiko ;

Kawai, Tomoji ;

Matsushita, Kazufumi ;

Hiiragi, Akane ;

Dermody, Terence S. ;

Fujita, Takashi ;

Akira, Shizuo .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (07) :1601-1610

[4] RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates [J].

Pichlmair, Andreas ;

Schulz, Oliver ;

Tan, Choon Ping ;

Naslund, Tanja I. ;

Liljestrom, Peter ;

Weber, Friedemann ;

Sousa, Caetano Reis E. .

SCIENCE, 2006, 314 (5801) :997-1001

[5] Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2 [J].

Saito, Takeshi ;

Hirai, Reiko ;

Loo, Yueh-Ming ;

Owen, David ;

Johnson, Cynthia L. ;

Sinha, Sangita C. ;

Akira, Shizuo ;

Fujita, Takashi ;

Gale, Michael, Jr. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (02) :582-587

[6] Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus [J].

Schlee, Martin ;

Roth, Andreas ;

Hornung, Veit ;

Hagmann, Cristina Amparo ;

Wimmenauer, Vera ;

Barchet, Winfried ;

Coch, Christoph ;

Janke, Markus ;

Mihailovic, Aleksandra ;

Wardle, Greg ;

Juranek, Stefan ;

Kato, Hiroki ;

Kawai, Taro ;

Poeck, Hendrik ;

Fitzgerald, Katherine A. ;

Takeuchi, Osamu ;

Akira, Shizuo ;

Tuschl, Thomas ;

Latz, Eicke ;

Ludwig, Janos ;

Hartmann, Gunther .

IMMUNITY, 2009, 31 (01) :25-34

[7] 5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I [J].

Schmidt, Andreas ;

Schwerd, Tobias ;

Hamm, Wolfgang ;

Hellmuth, Johannes C. ;

Cui, Sheng ;

Wenzel, Michael ;

Hoffmann, Franziska S. ;

Michallet, Marie-Cecile ;

Besch, Robert ;

Hopfner, Karl-Peter ;

Endres, Stefan ;

Rothenfusser, Simon .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (29) :12067-12072

[8] Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses [J].

Takahasi, Kiyohiro ;

Yoneyama, Mitsutoshi ;

Nishihori, Tatsuya ;

Hirai, Reiko ;

Kumeta, Hiroyuki ;

Narita, Ryo ;

Gale, Michael, Jr. ;

Inagaki, Fuyuhiko ;

Fujita, Takashi .

MOLECULAR CELL, 2008, 29 (04) :428-440

[9] RNA recognition and signal transduction by RIG-I-like receptors [J].

Yoneyama, Mitsutoshi ;

Fujita, Takashi .

IMMUNOLOGICAL REVIEWS, 2009, 227 :54-65

← 1 →