G protein-coupled receptors: Heterologous regulation of homologous desensitization and its implications

被引：212

作者：

Chuang, TT ^{[1
]}

Iacovelli, L ^{[1
]}

Sallese, M ^{[1
]}

DeBlasi, A ^{[1
]}

机构：

[1] IST RIC FARMACOL MARIO NEGRI,CONSORZIO MARIO NEGRI SUD,LAB MOL BIOL & PHARMACOL RECEPTORS,I-66030 SANTA MARIA IMBAR,ITALY

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1996年 / 17卷 / 11期

关键词：

D O I：

10.1016/S0165-6147(96)10048-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two patterns of rapid desensitization have been characterized for G protein-coupled receptors: homologous desensitizaton, which mainly involves G protein-coupled receptor kinases and arrestins, and heterologous desensitization, which mainly involves protein kinases A (PKA) and C (PKC). In this review, Tsu Tshen Chuang and colleagues discuss evidence to show that PKA and PKC can modify the functional state of the G protein-coupled receptor kinases/arrestin homologous desensitization machinery, providing a navel level of cross-talk in signal transduction. Studies on regulation of G protein-coupled receptor kinases and arrestins confirm that the functional state of this machinery may have important consequences for cellular responsiveness and may represent new targets for therapeutic strategies.

引用

页码：416 / 421

页数：6

共 51 条

[1] CHROMOSOMAL MAPPING OF THE GENES GPRK5 AND GPRK6 ENCODING G-PROTEIN-COUPLED RECEPTOR KINASES GRK5 AND GRK6 [J].