学术探索
学术期刊
新闻热点
数据分析
智能评审

CD20-mediated apoptosis: signalling through lipid rafts

被引：182
作者：
Deans, JP [1 ]
Li, HD [1 ]
Polyak, MJ [1 ]
机构：
[1] Univ Calgary, Dept Biochem & Mol Biol, Immunol Res Grp, Calgary, AB T2N 4N1, Canada
来源：
IMMUNOLOGY | 2002年 / 107卷 / 02期
关键词：
D O I：
10.1046/j.1365-2567.2002.01495.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
CD20 is an effective target for therapeutic B-cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity mediated via tyrosine kinase-dependent signalling pathways activated upon CD20 cross-linking. The association of CD20 with membrane microdomains known as lipid rafts, enriched in src-family tyrosine kinases and other signalling effectors, suggests an indirect mechanism of anti-CD20-induced apoptosis in which activation of src-family kinases occurs as a consequence of lipid raft clustering.
引用
收藏
页码：176 / 182
页数：7
相关论文
共 69 条
  • [1] Differential effects of filipin and methyl-β-cyclodextrin on B cell receptor signaling
    Awasthi-Kalia, M
    Schnetkamp, PPM
    Deans, JP
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 287 (01) : 77 - 82
  • [2] CD20 MONOCLONAL-ANTIBODIES DECREASE INTERLEUKIN-4-STIMULATED EXPRESSION OF THE LOW-AFFINITY RECEPTOR FOR IGE (FC-EPSILON-RII/CD23) IN HUMAN B-CELLS BY INCREASING THE EXTENT OF ITS CLEAVAGE
    BOURGET, I
    DIBERARDINO, W
    BREITTMAYER, JP
    GRENIERBROSSETTE, N
    PLANAPRADES, M
    BONNEFOY, JY
    COUSIN, JL
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (07) : 1872 - 1876
  • [3] CD20 MONOCLONAL-ANTIBODIES DOWN-REGULATE IGM AT THE SURFACE OF B-CELLS
    BOURGET, I
    BREITTMAYER, JP
    GRENIERBROSSETTE, N
    COUSIN, JL
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (03) : 768 - 771
  • [4] BOURGET I, 1994, J BIOL CHEM, V269, P6927
  • [5] Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase Csk and is involved in regulation of T cell activation
    Brdicka, T
    Pavilstová, D
    Leo, A
    Bruyns, E
    Korínek, V
    Angelisová, P
    Scherer, J
    Shevchenko, A
    Shevchenko, A
    Hilgert, I
    Cerny, J
    Drbal, K
    Kuramitsu, Y
    Kornacker, B
    Horejsí, V
    Schraven, B
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (09) : 1591 - 1604
  • [6] Structure and function of sphingolipid- and cholesterol-rich membrane rafts
    Brown, DA
    London, E
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (23) : 17221 - 17224
  • [7] TRANSFECTION OF THE CD20 CELL-SURFACE MOLECULE INTO ECTOPIC CELL-TYPES GENERATES A CA2+ CONDUCTANCE FOUND CONSTITUTIVELY IN B-LYMPHOCYTES
    BUBIEN, JK
    ZHOU, LJ
    BELL, PD
    FRIZZELL, RA
    TEDDER, TF
    [J]. JOURNAL OF CELL BIOLOGY, 1993, 121 (05) : 1121 - 1132
  • [8] The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction
    Byrd, JC
    Kitada, S
    Flinn, IW
    Aron, JL
    Pearson, M
    Lucas, N
    Reed, JC
    [J]. BLOOD, 2002, 99 (03) : 1038 - 1043
  • [9] Binding to CD20 by Anti-B1 Antibody or F(ab')2 is sufficient for induction of apoptosis in B-cell lines
    Cardarelli, PM
    Quinn, M
    Buckman, D
    Fang, Y
    Colcher, D
    King, DJ
    Bebbington, C
    Yarranton, G
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2002, 51 (01) : 15 - 24
  • [10] Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene
    Cartron, G
    Dacheux, L
    Salles, G
    Solal-Celigny, P
    Bardos, P
    Colombat, P
    Watier, H
    [J]. BLOOD, 2002, 99 (03) : 754 - 758
1234567