New insights into the role of serum amyloid P component, a novel lipopolysaccharide-binding protein

被引：43

作者：

de Haas, CJC ^{[1
]}

机构：

[1] Univ Utrecht, Dept Inflammat, Eijkman Winkler Inst, NL-3584 CX Utrecht, Netherlands

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 1999年 / 26卷 / 3-4期

关键词：

serum amyloid P component; pentraxin; Alzheimer's disease; lipopolysaccharide binding; lipopolysaccharide neutralization; gram-negative bacterium;

D O I：

10.1016/S0928-8244(99)00148-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serum amyloid P component (SAP) is a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. Although SAP is described to bind many ligands, no clear biological function has been ascribed to it as yet. This review summarizes the current knowledge about the protein SAP, its ligands and Functional properties. Finally, the author focuses on the recent finding of the binding of SAP to lipopolysaccharide (LPS) and Gram-negative bacteria and the possible functional consequences of these interactions. (C) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：197 / 202

页数：6

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