Tandem Metal and Organocatalysis in Sequential Hydroformylation and Enantioselective Mannich Reactions

被引：53

作者：

Chercheja, Serghei ^{[1
]}

Rothenbuecher, Thomas ^{[1
]}

Eilbracht, Peter ^{[1
]}

机构：

[1] Tech Univ Dortmund, Fachbereich Chem, D-44227 Dortmund, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 03期

关键词：

hydroformylation; Mannich reaction; organocatalysis; tandem reactions; TETRAHYDRO-BETA-CARBOLINES; ONE-POT; TRANSITION-METAL; CATALYSIS; ACID; 3-COMPONENT; COMBINATION; ALDEHYDES; ALCOHOLS; ENAMINE;

D O I：

10.1002/adsc.200800720

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Metal-catalysed hydroformylation is successfully combined with an organocatalysed stereoselective Mannich reaction in a tandem reaction sequence. This novel type of "tandem catalysis" allows access to complex molecular systems with high levels of enantioselectivity, using simple starting materials and an amino acid as the chiral catalyst.

引用

页码：339 / 344

页数：6

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