Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia

被引:286
作者
Shin, J
Cho, H
Hwang, SW
Jung, J
Shin, CY
Lee, SY
Kim, SH
Lee, MG
Choi, YH
Kim, J
Haber, NA
Reichling, DB
Khasar, S
Levine, JD
Oh, U
机构
[1] Seoul Natl Univ, Sensory Res Ctr, Natl Creat Res Initiat, Kwanak Gu, Seoul 151742, South Korea
[2] Seoul Natl Univ, Coll Pharm, Kwanak Gu, Seoul 151742, South Korea
[3] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
[5] Univ Calif San Francisco, Div Neurosci, San Francisco, CA 94143 USA
关键词
D O I
10.1073/pnas.152002699
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The capsaicin-sensitive vanilloid receptor (VR1) was recently shown to play an important role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown. We hypothesized that pain-producing inflammatory mediators activate capsaicin receptors by inducing the production of fatty acid agonists of VR1. This study demonstrates that bradykinin, acting at B2 bradykinin receptors, excites sensory nerve endings by activating capsaicin receptors via production of 12-lipoxygenase metabolites of arachidonic acid. This finding identifies a mechanism that might be targeted in the development of new therapeutic strategies for the treatment of inflammatory pain.
引用
收藏
页码:10150 / 10155
页数:6
相关论文
共 32 条
  • [1] Distinct structure-activity relations for stimulation of Ca-45 uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes
    Acs, G
    Lee, J
    Marquez, VE
    Blumberg, PM
    [J]. MOLECULAR BRAIN RESEARCH, 1996, 35 (1-2): : 173 - 182
  • [2] SYMPATHETIC AND AFFERENT SOMATA PROJECTING IN HINDLIMB NERVES AND THE ANATOMICAL ORGANIZATION OF THE LUMBAR SYMPATHETIC NERVOUS-SYSTEM OF THE RAT
    BARON, R
    JANIG, W
    KOLLMANN, W
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1988, 275 (03) : 460 - 468
  • [3] BURGESS GM, 1989, J NEUROSCI, V9, P3314
  • [4] Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    Caterina, MJ
    Leffler, A
    Malmberg, AB
    Martin, WJ
    Trafton, J
    Petersen-Zeitz, KR
    Koltzenburg, M
    Basbaum, AI
    Julius, D
    [J]. SCIENCE, 2000, 288 (5464) : 306 - 313
  • [5] The capsaicin receptor: a heat-activated ion channel in the pain pathway
    Caterina, MJ
    Schumacher, MA
    Tominaga, M
    Rosen, TA
    Levine, JD
    Julius, D
    [J]. NATURE, 1997, 389 (6653) : 816 - 824
  • [6] Ion channels gated by heat
    Cesare, P
    Moriondo, A
    Vellani, V
    McNaughton, PA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (14) : 7658 - 7663
  • [7] Specific involvement of PKC-ε in sensitization of the neuronal response to painful heat
    Cesare, P
    Dekker, LV
    Sardini, A
    Parker, PJ
    McNaughton, PA
    [J]. NEURON, 1999, 23 (03) : 617 - 624
  • [8] Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
    Chuang, HH
    Prescott, ED
    Kong, HY
    Shields, S
    Jordt, SE
    Basbaum, AI
    Chao, MV
    Julius, D
    [J]. NATURE, 2001, 411 (6840) : 957 - 962
  • [9] Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
    Davis, JB
    Gray, J
    Gunthorpe, MJ
    Hatcher, JP
    Davey, PT
    Overend, P
    Harries, MH
    Latcham, J
    Clapham, C
    Atkinson, K
    Hughes, SA
    Rance, K
    Grau, E
    Harper, AJ
    Pugh, PL
    Rogers, DC
    Bingham, S
    Randall, A
    Sheardown, SA
    [J]. NATURE, 2000, 405 (6783) : 183 - 187
  • [10] BRADYKININ INITIATES CYTOKINE-MEDIATED INFLAMMATORY HYPERALGESIA
    FERREIRA, SH
    LORENZETTI, BB
    POOLE, S
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1993, 110 (03) : 1227 - 1231