Ribose, galactose and glucose bis(thiosemicarbazone) complexes of copper(II) and nickel(II)

The bis(thiosemicarbazones) of glucose (GluTSCH(2)), galactose (GalTSCH(2)) and ribose (RibT-SCH2) were prepared and characterized by spectroscopic (H-1 and (CNMR)-C-13, UV, IR) methods. A complete assignment of the NMR signals was made using H-1-H-1 COSY; C-13-H-1 COSY; C-13 COLOC and NOEDIF techniques, complemented with theoretical calculations. Metal complexes with the general formula [M(bis TSC)I, where M = Cu-II, Ni-II and bisTSC = anion of the monosacchadde bts(thiosemicarbazones), were prepared and characterized. The X-band ESR power spectra of the copper(II) complexes show a rhombic distortion and the solution (DMF) ESR spectra indicate significant axial interaction with solvent molecules. The presence of the monosaccharide residue enhances the complexes' water solubility and increases their biological potential. (C) 1997 Elsevier Science Ltd.