Synthesis of optically active beta,gamma-alkynylglycine derivatives

Full results on the first synthesis of optically active beta,gamma-alkynylglycine derivatives from naturally occurring L-serine are described, The methodology uses L-serinal as a key intermediate and allows great versatility in the introduction of N-protective groups and of alkyne substitution. The N-Boc protected beta,gamma-alkynylglycine derivatives described have ee greater than 90%. Copyright (C) 1996 Elsevier Science Ltd