An Efficient Route to Rattle-Type Fe3O4@SiO2 Hollow Mesoporous Spheres Using Colloidal Carbon Spheres Templates

被引：241

作者：

Zhu, Yufang ^{[1
]}

Kockrick, Emanuel ^{[2
]}

Ikoma, Toshiyuki ^{[1
]}

Hanagata, Nobutaka ^{[1
]}

Kaskel, Stefan ^{[2
]}

机构：

[1] Natl Inst Mat Sci, ICYS Sengen, Tsukuba, Ibaraki 3050047, Japan

[2] Tech Univ Dresden, Inst Anorgan Chem, D-01069 Dresden, Germany

来源：

CHEMISTRY OF MATERIALS | 2009年 / 21卷 / 12期

关键词：

SUSTAINED-RELEASE PROPERTY; CONTROLLED DRUG-RELEASE; SILICA SPHERES; POLYMER MICROSPHERES; DELIVERY SYSTEM; SHELL STRUCTURE; GAS SENSORS; NANOPARTICLES; NANOCRYSTALS; FABRICATION;

D O I：

10.1021/cm900956j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Rattle-type Fe3O4@SiO2 hollow mesoporous spheres with large cavities have been successfully prepared by using the colloidal carbon spheres as the templates. The spheres are well monodisperse and nearly uniform in dimension with particle size of ca. 900 nm. The thickness of the mesoporous silica shell is about 100 nm, and only one Fe3O4 particle of ca. 100 nm in diameter is encapsulated in each hollow mesoporous silica sphere. The magnetic measurement indicated that the Fe3O4@SiO2 hollow mesoporous spheres exhibited ferromagnetic behavior with the magnetization saturation of 1.6 emu/g. Using aspirin as a model drug, the Fe3O4@SiO2 hollow mesoporous spheres showed high drug loading capacity and sustained release property. Therefore, this kind of magnetic hollow mesoporous spheres provides a very promising candidate for application in a targeted drug delivery system.

引用

页码：2547 / 2553

页数：7

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