Solid-phase synthesis of carbocyclic nucleosides

被引：39

作者：

Crimmins, MT ^{[1
]}

Zuercher, WJ ^{[1
]}

机构：

[1] Univ N Carolina, Venable & Kenan Labs Chem, Chapel Hill, NC 27599 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 08期

关键词：

D O I：

10.1021/ol005614n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient solid phase synthesis of carbocyclic nucleosides has been developed. The key step is the palladium catalyzed coupling of a purine derivative to a resin bound allylic benzoate, The resulting products may be further functionalized on the solid phase. Acidic cleavage affords carbocyclic nucleosides, a class of compounds with demonstrated biological activity and substantial current interest.

引用

页码：1065 / 1067

页数：3

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