Interleukin-8 secretion from Mycobacterium tuberculosis-infected monocytes is regulated by protein tyrosine kinases but not by ERK1/2 or p38 mitogen-activated protein kinases

被引：38

作者：

Ameixa, C ^{[1
]}

Friedland, JS ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Dept Infect Dis, London W12 0NN, England

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 08期

关键词：

D O I：

10.1128/IAI.70.8.4743-4746.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycobacterium tuberculosis upregulates NF-kappaB binding and interleukin-8 (IL-8) gene expression and secretion in primary human monocytes. Inhibition of tyrosine protein kinases but not of ERK1/2 or p38 mitogen-activated protein kinases downregulates tuberculosis-induced IL-8 secretion. The inhibitor genistein decreased NF-kappaB nuclear translocation and IL-8 gene transcription in addition to acting on posttranscriptional processing.

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收藏

页码：4743 / 4746

页数：4

相关论文

共 36 条

[1] Tumor necrosis factor-α activation of nuclear transcription factor-κB in marrow macrophages is mediated by c-Src tyrosine phosphorylatiola of IκBα [J].

Abu-Amer, Y ;

Ross, FP ;

McHugh, KP ;

Livolsi, A ;

Peyron, JF ;

Teitelbaum, SL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (45) :29417-29423

[2] Down-regulation of interleukin-8 secretion from Mycobacterium tuberculosis-infected monocytes by interleukin-4 and-10 but not by interleukin-13 [J].

Ameixa, C ;

Friedland, JS .

INFECTION AND IMMUNITY, 2001, 69 (04) :2470-2476

[3]

Bergeron A, 1997, J IMMUNOL, V159, P3034

[4] Cytokine levels correlate with a radiologic score in active pulmonary tuberculosis [J].

Casarini, M ;

Ameglio, F ;

Alemanno, L ;

Zangrilli, P ;

Mattia, P ;

Paone, G ;

Bisetti, A ;

Giosuè, S .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (01) :143-148

[5] The role of tyrosine phosphorylation in lipopolysaccharide- and zymosan-induced procoagulant activity and tissue factor expression in macrophages [J].

Dackiw, APB ;

Grinstein, S ;

Brisseau, GF ;

McGilvray, ID ;

Nathens, AB ;

McGuire, JA ;

Romanek, R ;

Cheung, PYC ;

Rotstein, OD .

INFECTION AND IMMUNITY, 1997, 65 (06) :2362-2370

[6]

FRIEDLAND JS, 1995, CLIN EXP IMMUNOL, V100, P233

[7]

FRIEDMAN PJ, 1992, ISSUES SCI TECHNOL, V8, P22

[8] MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions [J].

Gerszten, RE ;

Garcia-Zepeda, EA ;

Lim, YC ;

Yoshida, M ;

Ding, HA ;

Gimbrone, MA ;

Luster, AD ;

Luscinskas, FW ;

Rosenzweig, A .

NATURE, 1999, 398 (6729) :718-723

[9] Regulation of inducible gene expression by the transcription factor NF-κB [J].

Ghosh, S .

IMMUNOLOGIC RESEARCH, 1999, 19 (2-3) :183-190

[10] Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages [J].

Hambleton, J ;

Weinstein, SL ;

Lem, L ;

DeFranco, AL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (07) :2774-2778

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