Comparative genomics at the vertebrate extremes

被引：196

作者：

Boffelli, D

Nobrega, MA

Rubin, EM ^{[1
]}

机构：

[1] US DOE, Joint Genome Inst, Walnut Creek, CA 94598 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Lab, Genom Div, Berkeley, CA 94720 USA

来源：

NATURE REVIEWS GENETICS | 2004年 / 5卷 / 06期

关键词：

D O I：

10.1038/nrg1350

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Annotators of the human genome are increasingly exploiting comparisons with genomes at both the distal and proximal evolutionary edges of the vertebrate tree. Despite the sequence similarity between primates, comparisons among members of this clade are beginning to identify primate-as well as human-specific functional elements. At the distal evolutionary extreme, comparing the human genome to that of non-mammal vertebrates such as fish has proved to be a powerful filter to prioritize sequences that most probably have significant functional activity in all vertebrates.

引用

页码：456 / 465

页数：10

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