Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span

被引：224

作者：

Mitsui, A

Hamuro, J

Nakamura, H

Kondo, N

Hirabayashi, Y

Ishizaki-Koizumi, S

Hirakawa, T

Inoue, T

Yodoi, J

机构：

[1] Kyoto Univ, Dept Biol Responses, Inst Virus Res, Sakyo Ku, Kyoto 6068507, Japan

[2] Ajinomoto Co Inc, Pharmaceut Res Labs, Kawasaki Ku, Kawasaki, Kanagawa 2108681, Japan

[3] Natl Inst Hlth Sci, Cellular & Mol Toxicol Div, Biol Safety Res Ctr, Setagaya Ku, Tokyo 1588501, Japan

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2002年 / 4卷 / 04期

关键词：

D O I：

10.1089/15230860260220201

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transgenic (Tg) mice overexpressing human thioredoxin (TRX), a small redox-active protein, were produced to investigate the role of the protein in a variety of stresses. Bone marrow cells from TRX-Tg mice were more resistant to ultraviolet C-induced cytocide compared with those from wild type (WT) C57BL/6 mice. TRX-Tg mice exhibited extended median and maximum life spans compared with WT mice. Telomerase activity in spleen tissues in TRX-Tg mice was higher than that in WT mice. These results suggest that overexpression of TRX results in resistance against oxidative stress and a possible extension of life span without apparent abnormality in mammals.

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页码：693 / 696

页数：4

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