Beta-carotene antagonizes the effects of eicosapentaenoic acid on cell growth and lipid peroxidation in WiDr adenocarcinoma cells

被引：35

作者：

Palozza, P

Calviello, G

Maggiano, N

Lanza, P

Ranelletti, FO

Bartoli, GM

机构：

[1] Univ Cattolica Sacro Cuore, Inst Gen Pathol, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Inst Pathol, I-00168 Rome, Italy

[3] Univ Cattolica Sacro Cuore, Inst Histol, I-00168 Rome, Italy

[4] Univ Roma Tor Vergata, Dept Biol, Rome, Italy

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2000年 / 28卷 / 02期

关键词：

eicosapentaenoic acid; beta-carotene; cell growth; lipid peroxidation; free radicals;

D O I：

10.1016/S0891-5849(99)00225-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of combinations between eicosapentaenoic acid (EPA) and beta-carotene on cell growth and lipid peroxidation were investigated in human WiDr colon adenocarcinoma cells. EPA alone was able to inhibit the growth of WiDr cells in a dose- and time-dependent manner. Such an inhibition involved fatty acid peroxidation, as shown by the remarkable increase in the levels of Malondialdehyde (MDA) in EPA-treated cells. Beta-carotene was capable of reducing the growth inhibitory effects of EPA and the levels of MDA in a dose- and a time-dependent manner. In addition, EPA increased beta-carotene consumption in WiDr cells. This study provides evidence that beta-carotene can antagonize the effects of EPA on colon cancer cell growth and lipid peroxidation. (C) 2000 Elsevier Science Inc.

引用

页码：228 / 234

页数：7

共 48 条

[1] EFFECTS OF DIFFERENT DOSES OF FISH-OIL ON RECTAL CELL-PROLIFERATION IN PATIENTS WITH SPORADIC COLONIC ADENOMAS [J].