Medial septal lesions mimic effects of both selective dorsal and ventral hippocampal lesions

被引:54
作者
Bannerman, DM [1 ]
Matthews, P [1 ]
Deacon, RMJ [1 ]
Rawlins, JNP [1 ]
机构
[1] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England
基金
英国惠康基金;
关键词
D O I
10.1037/0735-7044.118.5.1033
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Electrolytic medial septal (MS) lesions, which depleted acetylcholinesterase staining in both dorsal and ventral hippocampus, produced a constellation of behaviors, combining aspects of both selective dorsal and ventral hippocampal lesion effects. MS lesions impaired spatial working memory on the T maze, thus resembling the effects of dorsal hippocampal lesions. In addition, MS lesions reduced anxiety during successive alleys (a modified form of the elevated plus-maze), social interaction, and hyponeophagia tests. MS lesions also reduced postshock freezing. These effects more closely resemble those of ventral hippocampal lesions. Therefore, the effects of electrolytic MS lesions derive from the resulting combined deafferentation of dorsal and ventral hippocampal regions, suggesting that previously reported effects of cytotoxic dorsal hippocampal lesions are unlikely to be due to a demyelination of fibers of passage coursing through the septal pole.
引用
收藏
页码:1033 / 1041
页数:9
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