Description of HLA class I- and CD8-deficient patients: Insights into the function of cytotoxic T lymphocytes and NK cells in host defense

被引：35

作者：

Cerundolo, Vincenzo ^{[1
]}

de la Salle, Henri

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[2] Estab Francais Sang Alsace, INSERM, Biol Dendrit Cells U725, F-67065 Strasbourg, France

来源：

SEMINARS IN IMMUNOLOGY | 2006年 / 18卷 / 06期

关键词：

primary immunodeficiency; bare lymphocyte syndrome; TAP deficiency; tapasin;

D O I：

10.1016/j.smim.2006.07.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Over the last few years, several patients with defects in the HLA class I presentation pathway have been described. Analysis of their clinical symptoms and immunological parameters have led to the identification of several unexpected findings which are of importance to understand the role of HLA class I-dependent immune responses in host defense. Here, we will describe and compare clinical manifestations and immunological findings of patients with defects in the peptide transporter proteins (TAP complex), tapasin and CD8 molecules. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：330 / 336

页数：7

共 64 条

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