p53 and metabolism: Inside the TIGAR

被引：195

作者：

Green, Douglas R. ^{[1
]}

Chipuk, Jerry E. ^{[1
]}

机构：

[1] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

CELL | 2006年 / 126卷 / 01期

关键词：

D O I：

10.1016/j.cell.2006.06.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The p53 tumor suppressor pathway coordinates DNA repair, cell-cycle arrest, apoptosis, and senescence to preserve genomic stability and prevent tumor formation. The discovery of three new target genes for p53 reveals unexpected functions for this tumor suppressor in the regulation of glucose metabolism and autophagy.

引用

页码：30 / 32

页数：3

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