Contribution of leg and splanchnic free fatty acid (FFA) kinetics to postabsorptive FFA flux in men and women

被引:66
作者
Jensen, MD [1 ]
Johnson, CM [1 ]
机构
[1] MAYO CLIN & MAYO FDN, DEPT RADIOL, ROCHESTER, MN 55905 USA
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 1996年 / 45卷 / 05期
关键词
D O I
10.1016/S0026-0495(96)90040-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We have previously shown that upper-body adipose tissue is more lipolytically active than lower-body adipose tissue in lean and obese women. The present studies were conducted to determine whether these regional differences are also present in men. Twenty-five lean, healthy men and 24 lean, healthy women underwent measures of body composition, postabsorptive systemic free fatty acid (FFA) flux, and leg and splanchnic FFA uptake and release. Upper-body adipose tissue was more lipolytically active than lower-body adipose tissue in both men (53.4 +/- 32.2 v 26.6 +/- 12.9 mu mol . kg fat(-1). min(-1), P < .001, respectively) and women (41.2 +/- 22.3 v 18.4 +/- 8.2 pmol . kg fat(-1). min(-1), P < .001, respectively). The correlations between leg FFA release and systemic FFA flux were modest in women and men (r = .38, P = .07 and r = .56, P = .003, respectively) as were the correlations between splanchnic FFA release and systemic FFA flux (r = .41, P = .06 and r = .40, P = .07, respectively). No effect of gender on the relationship between leg or splanchnic FFA release and systemic FFA flux was detected. In summary, upper-body FFA release is greater than lower-body FFA release in both men and women, and the relationship between leg or splanchnic FFA release and systemic FFA release is weak and similar in men and women. These findings suggest that regional differences in postabsorptive FFA kinetics are unlikely to be responsible for differences in regional fat distribution. (C) 1996 by W.B. Saunders Company.
引用
收藏
页码:662 / 666
页数:5
相关论文
共 26 条
[1]  
BASSO L V, 1970, Journal of Clinical Investigation, V49, P537, DOI 10.1172/JCI106264
[2]   ROLE OF GH IN REGULATING NOCTURNAL RATES OF LIPOLYSIS AND PLASMA MEVALONATE LEVELS IN NORMAL AND DIABETIC HUMANS [J].
BOYLE, PJ ;
AVOGARO, A ;
SMITH, L ;
BIER, DM ;
PAPPU, AS ;
ILLINGWORTH, DR ;
CRYER, PE .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (01) :E168-E172
[3]   THE ESTIMATION OF HEPATIC BLOOD FLOW IN MAN [J].
BRADLEY, SE ;
INGELFINGER, FJ ;
BRADLEY, GP ;
CURRY, JJ .
JOURNAL OF CLINICAL INVESTIGATION, 1945, 24 (06) :890-897
[4]   BODY-FAT DISTRIBUTION AND MALE-FEMALE DIFFERENCES IN LIPIDS AND LIPOPROTEINS [J].
FREEDMAN, DS ;
JACOBSEN, SJ ;
BARBORIAK, JJ ;
SOBOCINSKI, KA ;
ANDERSON, AJ ;
KISSEBAH, AH ;
SASSE, EA ;
GRUCHOW, HW .
CIRCULATION, 1990, 81 (05) :1498-1506
[5]   QUANTIFICATION OF BODY-FAT DISTRIBUTION IN THE ABDOMEN USING COMPUTED-TOMOGRAPHY [J].
GRAUER, WO ;
MOSS, AA ;
CANN, CE ;
GOLDBERG, HI .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1984, 39 (04) :631-637
[6]   ASSESSMENT OF BODY-COMPOSITION WITH USE OF DUAL-ENERGY X-RAY ABSORPTIOMETRY - EVALUATION AND COMPARISON WITH OTHER METHODS [J].
JENSEN, MD ;
KANALEY, JA ;
ROUST, LR ;
OBRIEN, PC ;
BRAUN, JS ;
DUNN, WL ;
WAHNER, HW .
MAYO CLINIC PROCEEDINGS, 1993, 68 (09) :867-873
[7]   CHOICE OF INFUSION-SAMPLING MODE FOR TRACER STUDIES OF FREE FATTY-ACID METABOLISM [J].
JENSEN, MD ;
ROGERS, PJ ;
ELLMAN, MG ;
MILES, JM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (05) :E562-E565
[8]   Effects of epinephrine on regional free fatty acid and energy metabolism in men and women [J].
Jensen, MD ;
Cryer, PE ;
Johnson, CM ;
Murray, MJ .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1996, 270 (02) :E259-E264
[9]   LIPOLYSIS DURING FASTING - DECREASED SUPPRESSION BY INSULIN AND INCREASED STIMULATION BY EPINEPHRINE [J].
JENSEN, MD ;
HAYMOND, MW ;
GERICH, JE ;
CRYER, PE ;
MILES, JM .
JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (01) :207-213
[10]   GENDER DIFFERENCES IN REGIONAL FATTY-ACID METABOLISM BEFORE AND AFTER MEAL INGESTION [J].
JENSEN, MD .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (05) :2297-2303