Interleukin 17 Production among Patients with American Cutaneous Leishmaniasis

被引：104

作者：

Bacellar, Olivia ^{[1
]}

Faria, Daniela ^{[2
]}

Nascimento, Marcia ^{[1
]}

Cardoso, Thiago M. ^{[1
]}

Gollob, Kenneth J. ^{[3
]}

Dutra, Walderez O. ^{[2
]}

Scott, Phillip ^{[4
]}

Carvalho, Edgar M. ^{[1
]}

机构：

[1] Univ Fed Bahia, Serv Imunol, Hosp Univ Prof Edgard Santos, BR-40110160 Salvador, BA, Brazil

[2] Univ Fed Minas Gerais, Dept Morfol, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Belo Horizonte, MG, Brazil

[4] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 200卷 / 01期

关键词：

MUCOSAL LEISHMANIASIS; CELL-ACTIVATION; T-CELLS; RESPONSES; GENERATION; INFECTIONS; RECEPTOR; FAMILY;

D O I：

10.1086/599380

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL-17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL-17 and the presence of cellular inflammation at the lesion site (r(2) = 0.86; P<.001). These data support the role of IL-17 in the pathogenesis of the inflammatory reaction in leishmaniasis.

引用

页码：75 / 78

页数：4

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