Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase

被引：42

作者：

Venkateswarlu, K ^{[1
]}

Cullen, PJ ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England

来源：

BIOCHEMICAL JOURNAL | 2000年 / 345卷

关键词：

ARNO; cytohesin-1; general receptor for phosphoinositides-1; phosphatidylinositol; 3-kinase;

D O I：

10.1042/0264-6021:3450719

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ADP-ribosylation factor (ARF) 6 regulates plasma membrane trafficking and cortical actin formation by cycling between inactive GDP and active GTP-bound conformations. Here we show that agonist stimulation of phosphatidylinositide 3-kinase (PI 3-kinase) activates a pathway that leads to ARF6 activation. We also describe experiments that propose a central role in this pathway for the PI 3-kinase-dependent plasma membrane recruitment of the cytohesin-1 family of PtdIns(3,4,5)P-3-binding ARF-exchange factors.

引用

页码：719 / 724

页数：6

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