Survivin expression and resistance to anticancer treatments: perspectives for new therapeutic interventions

被引:173
作者
Zaffaroni, N [1 ]
Daidone, MG [1 ]
机构
[1] Ist Nazl Studio & Cura Tumori, Dipartimento Oncol Sperimentale, Unita Operat 10, I-20133 Milan, Italy
关键词
survivin; apoptosis; anticancer drugs; ionizing radiation; antisense oligonucleotides; dominant negative mutants; ribozymes;
D O I
10.1016/S1368-7646(02)00049-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Survivin is a structurally unique member of the inhibitors of apoptosis protein (IAP) family that is involved in both control of cell division and inhibition of apoptosis. Its anti-apoptotic function seems to be related to its ability to directly or indirectly inhibit caspases, although the precise role of survivin in the modulation of the caspase cascade has not been fully elucidated. Survivin has been described to be selectively expressed in the most common human neoplasms and to be associated with clinical tumour progression. Moreover, the protein appears to be involved in tumour cell resistance to some anticancer agents and ionizing radiation. On the basis of these findings survivin has been proposed as a promising target for new anticancer interventions. In in vitro and in vivo studies targeting survivin with antisense oligonucleotides, dominant negative mutants or ribozymes have shown to induce apoptosis, reduce tumour-growth potential and sensitise tumour cells to chemotherapeutic drugs such as Taxol(R), cisplatin and etoposide, gamma-irradiation, and immunotherapy. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:65 / 72
页数:8
相关论文
共 48 条
[1]   The Bcl-2 protein family: Arbiters of cell survival [J].
Adams, JM ;
Cory, S .
SCIENCE, 1998, 281 (5381) :1322-1326
[2]   XA RECEPTOR EPR-1 [J].
ALTIERI, DC .
FASEB JOURNAL, 1995, 9 (10) :860-865
[3]  
Altieri DC, 1999, LAB INVEST, V79, P1327
[4]   A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma [J].
Ambrosini, G ;
Adida, C ;
Altieri, DC .
NATURE MEDICINE, 1997, 3 (08) :917-921
[5]   Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting [J].
Ambrosini, G ;
Adida, C ;
Sirugo, G ;
Altieri, DC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (18) :11177-11182
[6]   Survivin as a radioresistance factor in pancreatic cancer [J].
Asanuma, K ;
Moriai, R ;
Yajima, T ;
Yagihashi, A ;
Yamada, M ;
Kobayashi, D ;
Watanabe, N .
JAPANESE JOURNAL OF CANCER RESEARCH, 2000, 91 (11) :1204-1209
[7]   Does resistance to apoptosis affect clinical response to antitumor drugs? [J].
Borst, P ;
Borst, J ;
Smets, LA .
DRUG RESISTANCE UPDATES, 2001, 4 (02) :129-131
[8]   Apoptosis: mediator or mode of cell killing by anticancer agents? [J].
Brown, JM ;
Wouters, BG .
DRUG RESISTANCE UPDATES, 2001, 4 (02) :135-136
[9]   Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth [J].
Chen, J ;
Wu, W ;
Tahir, SK ;
Kroeger, PE ;
Rosenberg, SH ;
Cowsert, LM ;
Bennett, F ;
Krajewski, S ;
Krajewska, M ;
Welsh, K ;
Reed, JC ;
Ng, SC .
NEOPLASIA, 2000, 2 (03) :235-241
[10]  
Colella Gennaro, 2001, Proceedings of the American Association for Cancer Research Annual Meeting, V42, P302