Comparative evaluation of cefixime versus amoxicillin-clavulanate following ceftriaxone therapy of pneumonia

被引:11
作者
Amir, J
Harel, L
EidlitzMarkus, T
Varsano, I
机构
[1] HASHARON HOSP,DEPT PEDIAT,IL-49372 PETAH TIQWA,ISRAEL
[2] TEL AVIV UNIV,SACKLER SCH MED,IL-49100 PETAH TIQWA,ISRAEL
关键词
D O I
10.1177/000992289603501204
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Preliminary results have recently shown that an early switch from parenteral antimicrobials to an oral substitute provides an effective means of treating pneumonia in pediatric patients. In a controlled randomized study, 62 children with community-acquired lobar/segmental pneumonia were selected to receive 8 days of cefixime or amoxicillin-clavulanate after an initial therapy of two doses of parenteral ceftriaxone. Enrollment criteria included: age 6 months to 5 years, fever >38.5 degrees C, white blood cell (WBC) count greater than or equal to 15,000/mm(3), and lobar/segmental pneumonia on chest radiograph. Twenty-nine patients were randomized to receive oral cefixime and 33 to oral amoxicillin-clavulanate. The two groups were comparable in the following pretreatment parameters: age, duration of illness, temperature, mean WBC count, erythrocyte sedimentation rate, G-reactive protein, and need for hospitalization. Days of resolution of high fever, tachypnea, cough, grunting, and laboratory test abnormalities were similar in the two groups. Clinical response at the end of treatment showed cure, improvement, and failure in 97%, 3%, and 0%, respectively, in the cefixime group and in 885, 6%, and 6%, respectively in the amoxicillin-clavulanate group (P = NS). We conclude that young children with community-acquired lobar/segmental pneumonia can be successfully treated with 2 days of parenteral ceftriaxone followed by 8 days of oral cefixime or amoxicillin-clavulanate.
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页码:629 / 633
页数:5
相关论文
共 15 条
  • [1] CEFIXIME - SPECTRUM OF ANTIBACTERIAL ACTIVITY AGAINST 16016 CLINICAL ISOLATES
    BARRY, AL
    JONES, RN
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1987, 6 (10) : 954 - 957
  • [2] PARENTERAL-ORAL SWITCH IN THE MANAGEMENT OF PEDIATRIC PNEUMONIA
    DAGAN, R
    SYROGIANNOPOULOS, G
    ASHKENAZI, S
    ENGELHARD, D
    EINHORN, M
    GATZOLAKARAVELLI, M
    SHALIT, I
    AMIR, J
    [J]. DRUGS, 1994, 47 : 43 - 51
  • [3] DAGAN R, 1987, PEDIATR INFECT DIS J, V6, P1080, DOI 10.1097/00006454-198706120-00002
  • [4] DREWELOW B, 1993, 18 INT C CHEM STOCKH, P379
  • [5] GOOCH WM, 1985, CURR THER RES CLIN E, V37, P178
  • [6] GUATKUR DR, 1980, AM J PUBLIC HEALTH, V70, P1286
  • [7] COMPARATIVE, MULTICENTER STUDIES OF CEFIXIME AND AMOXICILLIN IN THE TREATMENT OF RESPIRATORY-TRACT INFECTIONS
    KIANI, R
    JOHNSON, D
    NELSON, B
    [J]. AMERICAN JOURNAL OF MEDICINE, 1988, 85 (3A) : 6 - 13
  • [8] ONCE-DAILY INTRAMUSCULAR CEFTRIAXONE IN THE OUTPATIENT TREATMENT OF SEVERE COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN
    LEIBOVITZ, E
    TABACHNIK, E
    FLIEDEL, O
    STEINBERG, S
    MISKIN, A
    ASKENAZI, A
    BARAK, Y
    [J]. CLINICAL PEDIATRICS, 1990, 29 (11) : 634 - 639
  • [9] NEIJENS V, 1993, 18 INT C CHEM STOCKH, P514