Identification and physiological evaluation of the components from Citrus fruits as potential drugs for anti-corpulence and anticancer

被引：68

作者：

Hirata, Toshifumi ^{[1
]}

Fujii, Misato ^{[1
]}

Akita, Kazuhiro ^{[1
]}

Yanaka, Noriyuki ^{[2
]}

Ogawa, Kaori ^{[2
]}

Kuroyanagi, Masanori ^{[3
]}

Hongo, Daiki ^{[3
]}

机构：

[1] Hiroshima Univ, Grad Sch Sci, Dept Math & Life Sci, Higashihiroshima 7398526, Japan

[2] Hiroshima Univ, Grad Sch Biosphere Sci, Dept Mol & Appl Biosci, Higashihiroshima 7398528, Japan

[3] Prefectural Univ Hiroshima, Fac Life & Environm Sci, Hiroshima 7270023, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 01期

关键词：

Cirtus fruits; Anti-corpulence; Anticancer; Polymethoxyflavones; Coumarin derivatives; CANCER CELLS; FLAVONOIDS; NOBILETIN; EXPRESSION; COUMARINS; PLANTS; JUICE; PEEL;

D O I：

10.1016/j.bmc.2008.11.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

On the basis of monitoring the prevention of accumulation of lipid droplets in mouse 3T3-L1 preadipocyte cells and inhibition of the proliferation of human colon cancer HT-29 cells, effective anti-corpulence and anticancer compounds were isolated from the peel of Citrus fruits. These bioactive components were identified as polymethoxyflavones and coumarin derivatives by spectroscopic analyses. 5-Hydroxy-6,7,8,3',4'-pentamethoxy. avone had the greatest anti-corpulence effects and 3,5,6,7,8,3',5'-heptamethoxyflavone had the greatest anticancer effects. Furthermore, distributions of those bioactive components in the peel of 10 species of Citrus fruits were demonstrated by HPLC analyses. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：25 / 28

页数：4

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