Combining checkpoint inhibitors and BRAF-targeted agents against metastatic melanoma

被引：36

作者：

Cooper, Zachary A. ^{[1
]}

Frederick, Dennie T. ^{[1
]}

Ahmed, Zain ^{[1
]}

Wargo, Jennifer A. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Div Surg Oncol, Boston, MA 02114 USA

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 05期

关键词：

BRAF; checkpoint blockade; immunotherapy; melanoma; PDL1; INFILTRATION; ANTIBODY; CANCER; SAFETY;

D O I：

10.4161/onci.24320

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The combination of BRAF-targeted agents with immune checkpoint inhibitors represents a recent advance in the treatment of melanoma, even though each of these therapeutic approaches alone has specific limitations. Increasing evidence suggests indeed the existence of a synergistic interaction between these therapeutic modalities.

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