Dependence of echovirus 9 on the enterovirus RNA replication inhibitor 2-(α-hydroxybenzyl)-benzimidazole maps to nonstructural protein 2C

被引：18

作者：

Hadaschik, D ^{[1
]}

Klein, M ^{[1
]}

Zimmermann, H ^{[1
]}

Eggers, HJ ^{[1
]}

Nelsen-Salz, B ^{[1
]}

机构：

[1] Univ Cologne, Inst Virol, D-50935 Cologne, Germany

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 12期

关键词：

D O I：

10.1128/JVI.73.12.10536-10539.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HBB [2-(alpha-hydroxybenzyl)-benzimidazole] selectively inhibits RNA synthesis of most enteroviruses. However, isolation of HBB-dependent variants is possible. Sequence analysis and characterization of recombinant, viruses revealed that HBB dependence maps to the nonstructural protein 2C. A single point mutation at position C4782U is sufficient to establish the HBB-dependent phenotype in our echovirus 9 model.

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页码：10536 / 10539

页数：4

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