A prospective 5-year follow-up study on the behavioral disturbances of community-dwelling elderly people with Alzheimer disease

被引:17
作者
Asada, T [1 ]
Kinoshita, T
Morikawa, T
Motonaga, T
Kakuma, T
机构
[1] Natl Ctr Neurol & Psychiat, Musashi Hosp, Div Old Age Psychiat, Kodaira, Tokyo 1870031, Japan
[2] HEC Sci Clin, Inst Diabet & Obes Treatment, Yokohama, Kanagawa, Japan
[3] Yamanashi Kosei Hosp, Nursing Div, Yamanashi, Japan
[4] Teikyo Univ, Sch Med, Dept Psychiat, Tokyo 173, Japan
[5] Cornell Univ, Med Ctr, New York Hosp, Dept Psychiat, New York, NY 10021 USA
关键词
Alzheimer disease; troublesome behavior; longitudinal study;
D O I
10.1097/00002093-199910000-00005
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The aim of the present study was to determine the longitudinal course of behavioral disturbances and to examine whether these disturbances are stage dependent during the course of Alzheimer disease (AD). One hundred seven community-dwelling patients with probable AD were assessed up to six times annually by using a validated and reliable rating scale, the Troublesome Behavior Scale, for assessing the frequencies of behavioral disturbances. The subjects were divided into three groups according to their baseline global function as assessed by the Clinical Dementia Rating (CDR; 1 = mild, 2 = moderate, 3 = severe). At the end of the 5-year observation period, 3 1 subjects were still active participants, 52 had died, 20 lived in institutions, and 4 had stopped participating. The patterns of their behavioral disturbance changes depended to a considerable extent on the baseline severity of the illness. The behavioral disturbance frequencies generally peaked at the CDR 2 stage and followed a downward trend thereafter. Considerable individual variations in the disturbance frequencies during the course of the illness were observed. Knowing the behavioral course of AD will enable clinicians to better counsel families and appraise the results of treatments for behavioral symptoms.
引用
收藏
页码:202 / 208
页数:7
相关论文
共 35 条
  • [1] Predictors of fall-related injuries among community-dwelling elderly people with dementia
    Asada, T
    Kariya, T
    Kinoshita, T
    Asaka, A
    Morikawa, S
    Yoshioka, M
    Kakuma, T
    [J]. AGE AND AGEING, 1996, 25 (01) : 22 - 28
  • [2] ASADA T, 1994, JPN J PUBLIC HLTH, V41, P518
  • [3] SURVIVAL IN ALZHEIMERS-DISEASE AND VASCULAR DEMENTIAS
    BARCLAY, LL
    ZEMCOV, A
    BLASS, JP
    SANSONE, J
    [J]. NEUROLOGY, 1985, 35 (06) : 834 - 840
  • [4] BARNES R, 1982, AM J PSYCHIAT, V139, P1170
  • [5] THE NATURAL-HISTORY OF ALZHEIMERS-DISEASE - DESCRIPTION OF STUDY COHORT AND ACCURACY OF DIAGNOSIS
    BECKER, JT
    BOLLER, F
    LOPEZ, OL
    SAXTON, J
    MCGONIGLE, KL
    MOOSSY, J
    HANIN, I
    WOLFSON, SK
    DETRE, K
    HOLLAND, A
    GUR, D
    LATCHAW, R
    BRENNER, R
    [J]. ARCHIVES OF NEUROLOGY, 1994, 51 (06) : 585 - 594
  • [6] MILD SENILE DEMENTIA OF THE ALZHEIMER TYPE .2. LONGITUDINAL ASSESSMENT
    BERG, L
    MILLER, JP
    STORANDT, M
    DUCHEK, J
    MORRIS, JC
    RUBIN, EH
    BURKE, WJ
    COBEN, LA
    [J]. ANNALS OF NEUROLOGY, 1988, 23 (05) : 477 - 484
  • [7] A LONGITUDINAL, BEHAVIORAL-STUDY OF SENILE DEMENTIA OF THE ALZHEIMER TYPE
    BOTWINICK, J
    STORANDT, M
    BERG, L
    [J]. ARCHIVES OF NEUROLOGY, 1986, 43 (11) : 1124 - 1127
  • [8] RELATION OF COGNITIVE STATUS AND ABNORMAL BEHAVIORS IN ALZHEIMERS-DISEASE
    COOPER, JK
    MUNGAS, D
    WEILER, PG
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1990, 38 (08) : 867 - 870
  • [9] THE PROGNOSIS IN ALZHEIMERS-DISEASE - HOW FAR RATHER THAN HOW FAST BEST PREDICTS THE COURSE
    DRACHMAN, DA
    ODONNELL, BF
    LEW, RA
    SWEARER, JM
    [J]. ARCHIVES OF NEUROLOGY, 1990, 47 (08) : 851 - 856
  • [10] FAMILY BURDEN IN THE CARE OF THE DEMENTED AND NONDEMENTED ELDERLY - A LONGITUDINAL-STUDY
    GRAFSTROM, M
    WINBLAD, B
    [J]. ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 1995, 9 (02) : 78 - 86