The Long Noncoding RNA IFNG-AS1 Promotes T Helper Type 1 Cells Response in Patients with Hashimoto's Thyroiditis

被引：58

作者：

Peng, Huiyong ^{[1
,2
]}

Liu, Yingzhao ^{[3
]}

Tian, Jie ^{[2
]}

Ma, Jie ^{[2
]}

Tang, Xinyi ^{[1
]}

Rui, Ke ^{[2
]}

Tian, Xinyu ^{[2
]}

Mao, Chaoming ^{[2
]}

Lu, Liwei ^{[4
]}

Xu, Huaxi ^{[2
]}

Jiang, Pengcheng ^{[5
]}

Wang, Shengjun ^{[1
,2
]}

机构：

[1] Jiangsu Univ, Affiliated Peoples Hosp, Dept Lab Med, Zhenjiang 212002, Peoples R China

[2] Jiangsu Univ, Inst Lab Med, Jiangsu Key Lab Lab Med, Sch Med, Zhenjiang 212013, Peoples R China

[3] Jiangsu Univ, Affiliated Peoples Hosp, Dept Endocrinol, Zhenjiang 212002, Peoples R China

[4] Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China

[5] Jiangsu Univ, Affiliated Peoples Hosp, Dept Gen Surg, Zhenjiang 212002, Peoples R China

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

中国国家自然科学基金;

关键词：

TRANSCRIPTION FACTOR; TH1; EXPRESSION; TMEVPG1; PATHOGENESIS; ACTIVATION; HOTAIR; INNATE; GENE;

D O I：

10.1038/srep17702

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The long noncoding (lnc) RNA-Ifng-AS1 plays an essential role in the transcription of the gene encoding IFN-gamma by Th1 cells, and its human ortholog, IFNG-AS1, is expressed in human Th1 cells. However, IFNG-AS1 contributing to Th1 cells' response in Hashimoto's thyroiditis (HT) patients has not been reported. Twenty-eight HT patients and 20 healthy controls were enrolled in the study. The proportion of circulating Th1 cells and the level of T-bet, IFNG mRNA were increased in HT patients, the expression of IFNG-AS1 was upregulated and positively correlated with the proportion of circulating Th1 cells or T-bet, and IFNG expression, or serum level of anti-thyroglobulin antibody/thyroperoxidase antibody in HT patients. IFNG-AS1 regulated the expression of IFNG at both transcriptional and translational level in human CD4(+) T cells. Furthermore, strong positive correlations between the increased transcript level of IFNG-AS1 and the increased transcript level of T-bet or IFNG were revealed in thyroid tissues from HT patients. Our results indicate that enhanced expression of lncRNA-IFNG-AS1 contributes to Th1 cell response in HT patients and may be involved in the pathogenesis of HT.

引用

页数：9

共 32 条

[1]

Autoimmune thyroid disorders [J].