K103N mutation in antiretroviral therapy-naive African patients infected with HIV type 1

被引：4

作者：

Akinsete, O

Hirigoyen, D

Cartwright, C

Schut, R

Kantor, R

Henry, K

机构：

[1] Univ Minnesota, Dept Infect Dis, Hennepin Cty Med Ctr, Minneapolis, MN 55455 USA

[2] Stanford Univ, Dept Med, Div Infect Dis, Palo Alto, CA 94304 USA

[3] Stanford Univ, Ctr AIDS Res, Palo Alto, CA 94304 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2004年 / 39卷 / 04期

关键词：

D O I：

10.1086/422519

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most of the information about genetic sequencing and drug susceptibility of human immunodeficiency virus type 1 (HIV-1) is derived from the study of HIV-1 subtype B. Worldwide, most people infected with HIV-1 are infected with non-subtype B viruses and live in developing countries. We report 3 cases of antiretroviral-naive African immigrants infected with HIV-1 strains possessing the K103N mutation in the reverse transcriptase gene, which confers high-level resistance to all nonnucleoside reverse transcriptase inhibitors.

引用

页码：575 / 578

页数：4

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