Thyroid disorders in chronic hepatitis C

被引:191
作者
Antonelli, A
Ferri, C
Pampana, A
Fallahi, P
Nesti, C
Pasquini, M
Marchi, S
Ferrannini, E
机构
[1] Univ Pisa, Sch Med, Dept Internal Med, I-56100 Pisa, Italy
[2] Univ Pisa, Sch Med, CNR, Inst Clin Physiol, I-56100 Pisa, Italy
[3] Santa Chiara Hosp, Rheumatol Unit, Pisa, Italy
[4] Santa Chiara Hosp, Div Med, Pisa, Italy
关键词
D O I
10.1016/j.amjmed.2004.01.023
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
PURPOSE: To explore the association of hepatitis C virus (HCV) infection with thyroid disorders. METHODS: We investigated the prevalence of thyroid disorders in 630 consecutive patients with chronic hepatitis due to HCV infection; all patients were free of cirrhosis and hepatocarcinoma, and were not on interferon treatment. Also included were a control group of 389 subjects from an iodine-deficient area, another control group of 268 persons living in an area of iodine sufficiency, and 86 patients >40 years of age with chronic hepatitis B. Levels of thyroid-stimulating hormone (TSH), free thyroxine (T-4), and triiodothyronine (T-3), as well as anti-thyroglobulin and anti-thyroid peroxidase antibodies, were measured. RESULTS: Mean TSH levels were higher (P = 0.001), and free T-3 and free T-4 levels were lower (P < 0.0001), in patients with chronic hepatitis C than in all other groups. Patients with chronic hepatitis C were more likely to have hypothyroidism (13% [n = 82]), anti-thyroglobulin antibodies (17% [n 108]), and anti-thyroid peroxidase antibodies (21% [n = 132]) than were any of the other groups. CONCLUSION: Both hypothyroidism and thyroid autoimmunity are more common in patients with chronic hepatitis C-even in the absence of cirrhosis, hepatocellular carcinoma, or interferon treatment-than in normal controls or those with chronic hepatitis B infection. (C) 2004 by Elsevier Inc.
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页码:10 / 13
页数:4
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