Micropatterning with aerosols:: Application for biomaterials

被引：12

作者：

Gagne, Louis

Rivera, Gerardo

Laroche, Gaetan ^{[1
]}

机构：

[1] Univ Laval, Fac Sci & Genie, Dept Genie Mines Met & Mat, Quebec City, PQ G1K 7P4, Canada

[2] CHUQ, Ctr Rech, Unite Biotechnol & Bioingn, Hop St Francois dAssise, Quebec City, PQ G1L 3L5, Canada

来源：

BIOMATERIALS | 2006年 / 27卷 / 31期

关键词：

cell adhesion; cell proliferation; cell spreading; endothelialization; micropatterning; RGD peptide;

D O I：

10.1016/j.biomaterials.2006.06.006

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Adhesion and proliferation behaviors of bovine aortic endothelial cells (BAECs) were investigated on surfaces micropatterned with peptides using a novel approach. This micropatterning technique allows modification of macroscopic three-dimensional (3D) biomaterials surfaces and exploits the semi-random properties of aerosols and the principles of liquid atomization. The possibility to control cell behaviors on polytetrafluoroethylene (PTFE) surfaces tailored with this micropatterning approach was evaluated. CGRGDS and CWQPPRARI peptides were selected for their adhesive, migration and spreading properties. Culture of BAECs on patterned PTFE showed the possibility of modulating cell behaviors. The study showed that CGRGDS spots with a diameter of 10 +/- 2 mu m over a background of CWQPPRARI peptides was the most effective combination to enhance endothelialization of PTFE. This micropatterning technique is innovative, easily adaptable, simple, and rapid for covering large 3D areas. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5430 / 5439

页数：10

共 47 条

[1]

AKHTAR SW, 1999, EXPT APPROACH PRODUC, P1

[2] Cell-to-cell contact and extracellular matrix - Editorial overview [J].