An efficient catalyst for Pd-catalyzed carbonylation of aryl arenesulfonates

被引：56

作者：

Cai, Chaoxian ^{[1
]}

Rivera, Nelo R. ^{[1
]}

Balsells, Jaume ^{[1
]}

Sidler, Rick R. ^{[1
]}

McWilliams, J. Christopher ^{[1
]}

Shultz, C. Scott ^{[1
]}

Sun, Yongkui ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Res Labs, Proc Res, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 22期

关键词：

D O I：

10.1021/ol062208g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aryl carboxylic esters were synthesized by Pd-catalyzed carbonylation of aryl p-fluorobenzenesulfonates or -tosylates. A unique Josiphos ligand was discovered through high-throughput catalyst screening, which was the key for the successful carbonylation of various substrates. This catalyst is effective and works well for both electron-rich and electron-poor aryl arenesulfonates. Isolated yields of up to 90% were obtained for aryl p-fluorobenzenesulfonates and -tosylates.

引用

页码：5161 / 5164

页数：4

共 18 条

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