Impact of pulmonary regurgitation and right ventricular dysfunction on oxygen uptake recovery kinetics in repaired tetralogy of Fallot

被引:41
作者
Giardini, Alessandro
Specchia, Salvatore
Coutsoumbas, Gloria
Donti, Andrea
Formigari, Roberto
Fattori, Rossella
Oppido, Guido
Gargiulo, Gaetano
Picchio, Fernando M.
机构
[1] Univ Bologna, Pediat Cardiol & Adult Congen Unit, I-40138 Bologna, Italy
[2] Univ Bologna, Inst Cardiol, Bologna, Italy
[3] Univ Bologna, Div Radiol, Bologna, Italy
关键词
tetralogy of Fallot; echocardiography; cardiopulmonary exercise testing; congenital heart defects; magnetic resonance imaging;
D O I
10.1016/j.ejheart.2006.01.012
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Background: Patients with repaired tetralogy of Fallot (ToF) featuring severe pulmonary regurgitation (PR) and/or right ventricular (RV) dysfunction have reduced exercise tolerance. Aims: To assess the impact of PR and of RV function on the ability to recover from exercise in ToF patients. Methods: 61 consecutive patients aged 23.1 +/- 12.1 years underwent maximal cardiopulmonary exercise test (CPX), transthoracic echocardiography and magnetic resonance imaging. This data was compared to those of 153 matched healthy subjects. Results: 19 patients (31%) had severe PR. RV dysfunction was noted in 19 patients (31%). Nine patients (15%) had both severe PR and RV dysfunction. Patients had lower peak oxygen uptake (VO2), VO2 slope, carbon dioxide production (VCO2) slope and O-2 pulse slope (P < 0.0001), especially those with severe PR and RV dysfunction (p < 0.000 1). Heart rate slope was similar between groups. No patient with severe PR and RV dysfunction had a predicted peak VO2 > 40%. CPX had a high sensitivity and specificity to identify patients with severe PR and RV dysfunction. Conclusions: In ToF patients, severe PR and RV dysfunction lead to delayed recovery from exercise. CPX can identify patients with severe PR and RV dysfunction and may be useful to guide the pulmonary valve replacement decision-making process. (c) 2006 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:736 / 743
页数:8
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