Polyoxometalate-Driven Self-Assembly of Short Peptides into Multivalent Nanofibers with Enhanced Antibacterial Activity

被引：141

作者：

Li, Jingfang ^{[1
]}

Chen, Zhijun ^{[1
]}

Zhou, Mengcheng ^{[1
]}

Jing, Jiangbo ^{[1
]}

Li, Wen ^{[1
]}

Wang, Yang ^{[1
]}

Wu, Lixin ^{[1
]}

Wang, Liyan ^{[1
]}

Wang, Yanqiu ^{[1
]}

Lee, Myongsoo ^{[1
]}

机构：

[1] Jilin Univ, State Key Lab Supramol Struct & Mat, Qianjin Ave 2699, Changchun 130012, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 07期

关键词：

bioactivity; ionic self-assembly; multivalent nanofibers; polyoxometalates; short peptides; MEMBRANES; DELIVERY; DRUG;

D O I：

10.1002/anie.201511276

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multivalent peptide nanofibers have attracted intense attention as promising platforms, but the fabrication of those nanofibers is mainly dependent on the spontaneous assembly of beta-sheet peptides. Herein we report an alternative approach to the creation of nanofibers: the polyoxometalatedriven self-assembly of short peptides. The resultant nanofibers with concentrated positive charges are excellent multivalent ligands for binding with bacterial cells and thus lead to a salient improvement in bioactivity.

引用

页码：2592 / 2595

页数：4

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