In vitro antimicrobial activity and MIC quality control guidelines of RPR 106972 (RPR 112808 RPR106950): A novel orally administered streptogramin combination

RPR 106972 is a novel oral streptogramin combination with reported therapeutic potency against Gram-positive and certain respiratory tract pathogens. MICs for RPR 106972, quinupristin/dalfopristin, and seven comparison drugs were determined by the reference methods against 337 strains selected to define spectrum and potency. RPR 106972 demonstrated antimicrobial activity against oxacillin-susceptible and -resistant Staphylococcus aureus (MIG ranges of 0.12 to 2 mu g/ml and 0.5 to 2 mu g/ml, respectively), and coagulase-negative staphylococci were also inhibited by RPR 106972 (MIC90, less than or equal to 0.5 mu g/ml) and quinupristin/dalfopristin (MIC90, less than or equal to 0.25 mu g/ml). Against all streptococcal strains ts tested (including penicillin-resistant pneumococcus), RPR 106972 was highly active with MIC results at less than or equal to 1 mu g/ml. RPR 106972 inhibited Corynebacterium jeikeium (MIC90, 0.5 mu g/ml), Moraxella catarrhalis (MIC90, 0.25 mu g/ml), and some Haemophilus influenzae (MIC50, 2 mu g/ml). RPR 106972 and quinupristin/dalfopristin demonstrated little activity against Enterococcus faecalis (MIC(90)s, 4 to 32 mu g/ml) as compared to Enterococcus faecium (MIC(90)s, 0.5 to I mu g/ml) and other Enterococcus ssp. (MIC(90)s, 1 mu g/ml). Studies to establish MIC quality-control guidelines indicated the following ranges: for E. faecalis ATCC 29212, 0.5 to 4 mu g/ml; for S. aureus ATCC 29213, 0.25 to 2 mu g/ml; and for Streptococcus pneumoniae ATCC 49619, 0.06 to 0.5 mu g/ml. The results of this study indicate that the in vitro activity of RPR 106972 against Gram-positive bacteria and selected Gram-negative respiratory organisms is promising and warrants additional studies of pharmacokinetics, and in vivo infection model dynamics. (C) 1997 Elsevier Science Inc.