The players on the γ-secretase team

被引:6
作者
Takashima, Akihiko [1 ]
Shimojo, Masafumi
Wolozin, Benjamin
机构
[1] RIKEN, Brain Sci Inst, Lab Alzheimers Dis, Wako, Saitama 3510198, Japan
[2] Boston Univ, Sch Med, Dept Pharmacol, Boston, MA 02118 USA
关键词
D O I
10.1038/nm0706-766
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A beta generation requires gamma-secretase activity. Inhibition of gamma-secretase may now be easier due to the recent identification of the four proteins that make up the gamma-secretase complex.
引用
收藏
页码:766 / 767
页数:2
相关论文
共 14 条
[1]   Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila [J].
Chung, HM ;
Struhl, G .
NATURE CELL BIOLOGY, 2001, 3 (12) :1129-1132
[2]  
DE SB, 1999, NATURE, V398, P518
[3]   Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein [J].
De Strooper, B ;
Saftig, P ;
Craessaerts, K ;
Vanderstichele, H ;
Guhde, G ;
Annaert, W ;
Von Figura, K ;
Van Leuven, F .
NATURE, 1998, 391 (6665) :387-390
[4]   Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum [J].
Dermaut, B ;
Kumar-Singh, S ;
Rademakers, R ;
Theuns, J ;
Cruts, M ;
Van Broeckhoven, C .
TRENDS IN GENETICS, 2005, 21 (12) :664-672
[5]   RETRACTED: γ-cleavage-independent functions of presenilin, nicastrin, and aph-1 regulate cell-junction organization and prevent tau toxicity in vivo (Retracted article. See vol. 53, pg. 463, 2007) [J].
Doglio, Laura E. ;
Kanwar, Ritu ;
Jackson, George R. ;
Perez, Mar ;
Avila, Jesus ;
Dingwal, Colin ;
Dotti, Carlos G. ;
Fortini, Mark E. ;
Feiguin, Fabian .
NEURON, 2006, 50 (03) :359-375
[6]   Reconstitution of γ-secretase activity [J].
Edbauer, D ;
Winkler, E ;
Regula, JT ;
Pesold, B ;
Steiner, H ;
Haass, C .
NATURE CELL BIOLOGY, 2003, 5 (05) :486-488
[7]   aph-1 and pen-2 are required for notch pathway signaling, γ-secretase cleavage of βAPP, and presenilin protein accumulation [J].
Francis, R ;
McGrath, G ;
Zhang, JH ;
Ruddy, DA ;
Sym, M ;
Apfeld, J ;
Nicoll, M ;
Maxwell, M ;
Hai, B ;
Ellis, MC ;
Parks, AL ;
Xu, W ;
Li, JH ;
Gurney, M ;
Myers, RL ;
Himes, CS ;
Hiebsch, R ;
Ruble, C ;
Nye, JS ;
Curtis, D .
DEVELOPMENTAL CELL, 2002, 3 (01) :85-97
[8]   APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos [J].
Goutte, C ;
Tsunozaki, M ;
Hale, VA ;
Priess, JR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :775-779
[9]   Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1 [J].
Li, YM ;
Xu, M ;
Lai, MT ;
Huang, Q ;
Castro, JL ;
DiMuzio-Mower, J ;
Harrison, T ;
Lellis, C ;
Nadin, JL ;
Neduvelil, JG ;
Register, RB ;
Sardana, MK ;
Shearman, MS ;
Smith, AL ;
Shi, XP ;
Yin, KC ;
Shafer, JA ;
Gardell, SJ .
NATURE, 2000, 405 (6787) :689-694
[10]   Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease [J].
Scheuner, D ;
Eckman, C ;
Jensen, M ;
Song, X ;
Citron, M ;
Suzuki, N ;
Bird, TD ;
Hardy, J ;
Hutton, M ;
Kukull, W ;
Larson, E ;
LevyLahad, E ;
Viitanen, M ;
Peskind, E ;
Poorkaj, P ;
Schellenberg, G ;
Tanzi, R ;
Wasco, W ;
Lannfelt, L ;
Selkoe, D ;
Younkin, S .
NATURE MEDICINE, 1996, 2 (08) :864-870