'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

被引:6146
作者
Nicholson, JK [1 ]
Lindon, JC [1 ]
Holmes, E [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Div Biomed Sci, London SW7 2AZ, England
关键词
D O I
10.1080/004982599238047
中图分类号
R9 [药学];
学科分类号
1007 [药学];
摘要
[No abstract available]
引用
收藏
页码:1181 / 1189
页数:9
相关论文
共 29 条
[1]
New insights into cyclosporine A nephrotoxicity by proteome analysis [J].
Aicher, L ;
Wahl, D ;
Arce, A ;
Grenet, O ;
Steiner, S .
ELECTROPHORESIS, 1998, 19 (11) :1998-2003
[2]
Simultaneous measurement of hundreds of liver proteins: Application in assessment of liver function [J].
Anderson, NL ;
Taylor, J ;
Hofmann, JP ;
EsquerBlasco, R ;
Swift, S ;
Anderson, NG .
TOXICOLOGIC PATHOLOGY, 1996, 24 (01) :72-76
[3]
ANTHONY ML, 1994, MOL PHARMACOL, V46, P199
[4]
BALES JR, 1984, CLIN CHEM, V30, P426
[5]
Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins [J].
Beckwith-Hall, BM ;
Nicholson, JK ;
Nicholls, AW ;
Foxall, PJD ;
Lindon, JC ;
Connor, SC ;
Abdi, M ;
Connelly, J ;
Holmes, E .
CHEMICAL RESEARCH IN TOXICOLOGY, 1998, 11 (04) :260-272
[6]
*C EL SEQ CONS, 1998, SCIENCE 1211, P2041
[7]
MECHANISM OF S-(1,2-DICHLOROVINYL)GLUTATHIONE-INDUCED NEPHROTOXICITY [J].
ELFARRA, AA ;
JAKOBSON, I ;
ANDERS, MW .
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (02) :283-288
[8]
GARTLAND KPR, 1989, MOL PHARMACOL, V35, P242
[9]
GARTLAND KPR, 1991, MOL PHARMACOL, V39, P629
[10]
Proteomics: One small step for a digital computer, one giant leap for humankind [J].
Geisow, MJ .
NATURE BIOTECHNOLOGY, 1998, 16 (02) :206-206