First synthesis of 3-acetyl-2-aminothiophenes using the Gewald reaction

被引：29

作者：

Eller, Gernot A. ^{[1
]}

Holzer, Wolfgang ^{[1
]}

机构：

[1] Univ Vienna, Fac Life Sci, Dept Drug Synth, A-1010 Vienna, Austria

来源：

MOLECULES | 2006年 / 11卷 / 05期

关键词：

Gewald reaction; thiophene synthesis; cyclization; condensation;

D O I：

10.3390/11050371

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel 3-acetyl-2-aminothiophenes were prepared from cyanoacetone and 1,4-dithianyl-2,5-diols using a modified Gewald reaction. The syntheses of the corresponding acetamides, as well as that of 3-acetyl-2-amino-5-nitrothiophene - an interesting building-block for thiophene azo dyes - are reported. Detailed spectroscopic investigations (H-1-NMR, C-13-NMR, MS, IR) of the obtained compounds are presented.

引用

页码：371 / 376

页数：6

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