Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications

被引：121

作者：

Collighan, R. J. ^{[1
]}

Griffin, M. ^{[1
]}

机构：

[1] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England

来源：

AMINO ACIDS | 2009年 / 36卷 / 04期

关键词：

Tissue transglutaminase; TG2; Biomaterials; Extracellular matrix; Cross-linking; CHONDROCYTE HYPERTROPHIC DIFFERENTIATION; TISSUE-TYPE TRANSGLUTAMINASE; INDEPENDENT CELL-ADHESION; COAGULATION-FACTOR XIII; EXTRACELLULAR-MATRIX; SURFACE TRANSGLUTAMINASE; MICROBIAL TRANSGLUTAMINASE; TRABECULAR MESHWORK; KAPPA-B; COLLAGEN;

D O I：

10.1007/s00726-008-0190-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review summarises the functions of the enzyme tissue transglutaminase (TG2) in the extracellular matrix (ECM) both as a matrix stabiliser through its protein cross-linking activity and as an important cell adhesion protein involved in cell survival. The contribution of extracellular TG2 to the pathology of important diseases such as cancer and fibrosis are discussed with a view to the potential importance of TG2 as a therapeutic target. The medical applications of TG2 are further expanded by detailing the use of transglutaminase cross-linking in the development of novel biocompatible biomaterials for use in soft and hard tissue repair.

引用

页码：659 / 670

页数：12

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