A new trigger for T cells

被引：42

作者：

Davis, MM ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

来源：

CELL | 2002年 / 110卷 / 03期

关键词：

D O I：

10.1016/S0092-8674(02)00865-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Understanding the early events in T cell activation and signaling is an active area of research. A recent study (Gil et al, 2002) has described a new trigger for T cell activation, involving a TCR-ligand-induced conformational change in CD3epsilon that permits binding of the adaptor protein Nck.

引用

页码：285 / 287

页数：3

共 16 条

[1]

Aivazian D, 2000, NAT STRUCT BIOL, V7, P1023

[2] The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers [J].

Cochran, JR ;

Cameron, TO ;

Stern, LJ .

IMMUNITY, 2000, 12 (03) :241-250

[3] Ligand recognition by αβ T cell receptors [J].

Davis, MM ;

Boniface, JJ ;

Reich, Z ;

Lyons, D ;

Hampl, J ;

Arden, B ;

Chien, YH .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :523-+

[4] Multivalent structure of an αβT cell receptor [J].

Fernández-Miguel, G ;

Alarcón, B ;

Iglesias, A ;

Bluethmann, H ;

Alvarez-Mon, M ;

Sanz, E ;

de la Hera, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (04) :1547-1552

[5] Recruitment of Nck by CD3ε reveals a Ligand-Induced conformational change essential for T cell receptor signaling and synapse formation [J].

Gil, D ;

Schamel, WWA ;

Montoya, M ;

Sánchez-Madrid, F ;

Alarcón, B .

CELL, 2002, 109 (07) :901-912

[6] Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone [J].

He, XL ;

Chow, DC ;

Martick, MM ;

Garcia, KC .

SCIENCE, 2001, 293 (5535) :1657-1662

[7]

Lin J, 2001, J CELL SCI, V114, P243

[8] Conformational changes of ribose-binding protein and two related repressors are tailored to fit the functional need [J].

Mowbray, SL ;

Björkman, AJ .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 294 (02) :487-499

[9] A piston model for transmembrane signaling of the aspartate receptor [J].

Ottemann, KM ;

Xiao, WZ ;

Shin, YK ;

Koshland, DE .

SCIENCE, 1999, 285 (5434) :1751-1754

[10] ANTIGEN RECEPTOR TAIL CLUE [J].

RETH, M .

NATURE, 1989, 338 (6214) :383-384

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